For the IL-1B I take high doses of D3, TUDCA, and DIM. For the dysautonomia aspect I take Low Dose Naltrexone, a lower dose of modafinil in the morning and amitryptiline at night. I prefer weaker psychopharmacology ligands as it’s preferable to work with the natural rhythms of the body instead of fighting them.

I have a strict near zero sugar diet that’s high in kale. I take a low dose of semaglutide (ozempic) which has been one of the best meds I’ve tried. I make sure I get enough UV exposure. I’ve done Test Cyp and Ipamorelin/ModGRF and they do help a lot but I stopped taking them when semaglutide worked so well. I highly suspect people with hEDS are highly sensitive to semaglutide and should start and stay on much lower doses (1/10th) otherwise they’re near guaranteed to have a bad time.

I’m mostly interested in the TNXB subtype of hEDS which seems to have some weird comorbidities, like an intolerance to noise, a touch of ADHD, obstinate personality, difficulty falling asleep, local and general anesthetic resistance, and an unusually high IQ. There is an unusual reaction to medications with most medications working less than expected.

A good list of comorbidities that could help make a self diagnosis; https://ohtwist.com/about-eds/comorbidities