> which seems to have some weird comorbidities

I'm a bit shocked by your list of comorbidities. Not only yours, but also the one you linked to. MCAS is currently among my most pressing concerns, although it seems to be getting under control with H1 and H2 antihistamines + cromoglycate. An anti inflammatory diet also helps, even though I'm struggling to stay completely away from sugar. The psychiatric part calls my attention. I also present some traits of ADHD and ASD, although not enough to complete a diagnosis. Twenty years ago I joined mensa at the 99th percentile, but I do believe my IQ has decreased significantly since then. I can't even remember the last time I had, in my adulthood, my mind as functional as I used to have in my teenagehood, even before covid and the aggravation of the symptoms.

Out of your list, the only item I couldn't relate with were the medications working less than expected. In my case, I usually have stronger effects, both therapeutic and side ones. That happens with vaccines too. However, last weekend I took one for Influenza and the side effects were barely noticeable for the first time in my adult life -- I hope that's a result of the MCAS treatment.