Chemically induced reprogramming to reverse cellular aging [1] a.k.a. OSKM
My first experiments would be on some really old horses. I could probably buy a 30 year old horse from a neighbor. She is on her last leg. I want to make her younger again and then just let her have many more years of chilling and not having to make babies every year. If can learn this well enough to reverse the age of a dozen horses then my second test subject would be myself. If I get that right then my friends could optionally do the same.
* Did I miss a tone indicator (/s) in your response?
* If not, why do you think that transcriptional reprogramming of fibroblast cells in culture (as per the Yang et al. paper you cite), which results in "reversing trancriptomic age" can be applied to whole organisms?
* Ignoring the "de-aging" horses bit, is it realistic to think that getting a handle on the science behind cellular reprogramming is really just a 100 hour task?
Because it has been for several years in mice and monkeys.
really just a 100 hour task?
To learn, yes. It is a well established process. Mice have been aged, de-aged, aged, de-aged using this process. One can find videos on Youtube from Dr. Sinclairs team that show the mice and their physical abilities during the entire process. This has also been used on humans specifically in the optic nerves but it won't be long before it is approved for body-wide usage. I would not expect the learning process to exceed 72 hours not counting breaks.
Did you know there were verification competitions? [0]
[0] https://alastairreid.github.io/verification-competitions/
I can type quickly through my own means but very inaccurately. In a recent fast-paced online game the other players assumed I wasn't a native English speaker due to all my typos. I was a Vim user for ten years and would constantly mash the wrong keys. After starting touch-typing a few days ago, I redownloaded the old Vimfx extension to control my web browser from my keyboard. It ended up requiring me to switch to a Firefox fork called Waterfox though, as the modern (post-2017) extensions have to rely on injecting Javascript into the page and don't work well.
Do it. You can learn in like 15 minutes a day over a few weeks.
But it's actually surprising on mobile how much easier a non-QWERTY keyboard is considering it's two thumbs and your thumbs are at the pinky areas most of the time.
It took me a few months on keybr honestly when I got a new, ergonomic keyboard. The problem with ergo keyboards is they're split at the middle and suddenly my left hand couldn't reach for what was on the right side like it normally would and I had never realized I was doing it "wrong" all this time.
But I still can't easily figure out to deploy my apps to a VPS.
So far I have manually set up my server and database.
I want learn more on devops to deploy it using containers.
This will enable me to host mutiple service in a VPS and I don't have to use PAAS solutions.
I can also easily switch providers too.
In general, though, since I believe I’ll lose my job to AI, I’d like to learn and become an electrician.
Frontend Masters might be worth checking out.
The Argentinians have a unique approach to the Milonguero style which I’m interested in so in this case they need to be from Argentina ;)
Another option would be one of my other interests, again, spent one on one with a world-class instructor and intentional practice.
Otherwise, Blender. Been using it at work for a left field innovation project and I'm kind of hooked.
I assume the first case, i.e. you have about 4 days to learn something. I'd recommend taking up some paid, intensive training as most such trainings take about 3-5 days and you can maximize the learning during the 4 days of timeframe.
2. CSS tricks and animation. While other people try to race on Leetcode, my personal favorite is CodePen.
3. Probably learn Flutter and React properly instead of just going in blind and editing code.
In that case, I'd probably choose first-aid & the basics of emergency medicine via a couple of half-day or a full-day course per year.
If I wanted to do something completely new I might dive into more detail around security/pen testing although I've noticed that a lot of companies doing this just seem to run a lot of off the shelf tools these days.
Theory of relativity. I’ve never quite been able to wrap my head around it. Given some free time, I would really want to understand how two simple postulates can lead to such far-reaching conclusions.
Mathematical reasoning is a superpower. Most of what is worth learning is some specific case of more general reasoning and at the root of general reasoning lies mathematics.
There's no substitute for domain expertise, of course. But being good at generalized reasoning really helps absorb and question domain knowledge (not only in the sense of challenging but also querying), which helps interact productively with specialized domain experts.
100%. Tons of self taught folks have glaring gaps in their education when it comes to stuff like patterns and algorithms and make weird mistakes because of it.
125 days in. Almost through Fundamentals II.
Careers are made of people not knowledge. Good luck.
