We've adopted the more neutral subtitle now.
Oh, it's your own teeth they use. That answers one question.
> Many studies have shown the incidence of repair procedures and worse final vision outcomes were higher in groups with autoimmune conditions (SJS, OCP). The difference in outcomes appears to be related to the degree and cumulative past period of inflammation. Overall most favorable outcomes are achieved in non-cicatrizing conditions, followed by ocular burns and OCP with the worst outcomes in SJS patients.
The patient in the article was a SJS patient
> The massage therapist says he could see just fine until he was 13 years old, when he took some ibuprofen after a school basketball game, triggering a rare auto-immune reaction known as Stevens-Johnson syndrome.
Google Image Search:
https://www.google.com/search?udm=2&q=Boston+Keratoprosthesi...
Suggested headline: "Surgery implants tooth material in eye as scaffolding for lens" or something like that?
Grossness aside, it's pretty interesting that the need for biocompatibility made this something worth considering at all though.
Wisdom teeth often do require pulling cus they literally don't fit (idk if this is an evolution thing - were people losing teeth normally enough that a new one coming in wasn't overcrowding?)
[1]https://www.pittwire.pitt.edu/pittwire/features-articles/cur...
This surgery is for people who've had their eyes destroyed by chemicals or similar. They don't always have the structure remaining for any finer control.
"Hey peeps, I've been bouncing around this idea lately. So you know how Mrs Smith in room 230 has no eyesight left? Well one of her teeth came off when she fell last night, and I started thinking.."
https://scholar.google.com/scholar?q=related:ZlcYhwhYqiUJ:sc...
From "Clinical and Scientific Considerations for Whole Eye Transplantation: An Ophthalmologist's Perspective" (2025) https://tvst.arvojournals.org/article.aspx?articleid=2802568 :
> Whereas advances in gene therapy, neurotrophic factor administration, and electric field stimulation have shown promise in preclinical optic nerve crush injury models, researchers have yet to demonstrate efficacy in optic nerve transection models—a model that more closely mimics WET. Moreover, directing long-distance axon growth past the optic chiasm is still challenging and has only been shown by a handful of approaches. [5–8]
> Another consideration is that even if RGC axons could jump across the severed nerve ending, it would be impossible to guarantee maintenance of the retinal-cortical map. For example, if the left eye were shifted clockwise during nerve coaptation, RGCs in the superior-nasal quadrant of donor retinas would end up synapsing with superior-temporal neurons in the host's geniculate nucleus. This limitation also plagues RGC-specific transplantation approaches; its effect on vision restoration is unknown.
"Combined Whole Eye and Face Transplant: Microsurgical Strategy and 1-Year Clinical Course" (2024) https://pubmed.ncbi.nlm.nih.gov/39250113/ :
> Abstract: [...] Serial electroretinography confirmed retinal responses to light in the transplanted eye. Using structural and functional magnetic resonance imaging, the integrity of the transplanted visual pathways and potential occipital cortical response to light stimulation of the transplanted eye was demonstrated. At 1 year post transplant (postoperative day 366), there was no perception of light in the transplanted eye.
"Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review" (2023) https://journals.lww.com/prsgo/fulltext/2023/04000/Technical... :
> With nervous coaptation, 82.9% of retinas had positive electroretinogram signals after surgery, indicating functional retinal cells after transplantation. Results on optic nerve function were inconclusive. Ocular-motor functionality was rarely addressed.
How to target NGF(s) to the optic nerve?
Magnets? RF convergence?
How to resect allotransplant and allograft optic nerve tissue?
How to stimulate neuronal growth in general?
Near-infrared stimulates neuronal growth and also there's red light therapy.
Nanotransfection stimulates tissue growth by in-vivo stroma reprogramming.
How to understand the optic nerve portion of the connectome?
The Visual and Auditory cortices are observed to be hierarchical.
Near-field imaging of [optic] nerves better than standard VEP Visual Evoked Potential tests would enable optimization of [optic nerve] transection.
VEP: https://en.wikipedia.org/wiki/Evoked_potential#Visual_evoked...
Ophthalmologic science is important because - while it's possible to fight oxidation and aging - our eyes go.
Upper-atmospheric radiation is terrible on eyes. This could be a job for space medicine, and pilots.
Accomodating IOLs that resist UV damage better than natural tissue: Ocumetics
From "Portable low-field MRI scanners could revolutionize medical imaging" (2023) https://news.ycombinator.com/item?id=34990738 :
> Is MRI-level neuroimaging possible with just NIRS Near-Infrared Spectroscopy?
From "Language models can explain neurons in language models" https://news.ycombinator.com/item?id=35886145 :
> So, to run the same [fMRI, NIRS,] stimulus response activation observation/burn-in again weeks or months later with the same subjects is likely necessary given Representational drift.
"Reversible optical data storage below the diffraction limit (2023)" [at cryogenic temperatures] https://news.ycombinator.com/item?id=38528844 :
> [...] have successfully demonstrated that a beam of light can not only be confined to a spot that is 50 times smaller than its own wavelength but also “in a first of its kind” the spot can be moved by minuscule amounts at the point where the light is confined.
Optical tweezers operating below the Abbe diffraction limit are probably of use in resecting neurovascular tissue in the optic nerve (the retina and visual cortex)?
"Real-space nanophotonic field manipulation using non-perturbative light–matter coupling" (2023) https://opg.optica.org/optica/fulltext.cfm?uri=optica-10-1-1... :
>
"One can write, erase, and rewrite an infinite number of times,"*Fluoxetine increases plasticity in the adult visual cortex; https://news.ycombinator.com/item?id=43079501
Zebrafish can regrow eyes,
From the "What if Eye...?" virtual eyes in a petri dish simulation: https://news.ycombinator.com/item?id=43044958 :
> [ mTor in Axolotls, ]
"Reactivating Dormant Cells in the Retina Brings New Hope for Vision Regeneration" (2023) https://neurosciencenews.com/vision-restoration-genetic-2318... :
> “What’s interesting is that these Müller cells are known to reactivate and regenerate retina in fish,” she said. “But in mammals, including humans, they don’t normally do so, not after injury or disease. And we don’t yet fully understand why.”
/? Regenerative medicine for ophthalmologic applications
How fitting that the material usually comes from eyeteeth!
[English translation: https://music.youtube.com/watch?v=XX2GD7q7-wA&si=2ZuxnqxYxoT...]
