You can easily search for open issues, tag/label them, mange milestones, you know, project stuff. Plus you get a web interface that's a bit more user friendly than mailman's. You can see what's going on, how much open issues there are.
How hard it is to open N separate issues and link them to the original one? It's exactly as much effort as sending new emails.
TC39 uses GitHub: https://github.com/tc39/
There's also the IETF datatracker, and various sites cobbled together to show the mail threads (eg. https://mailarchive.ietf.org/arch/browse/acme/ ) and states of various RFCs. And basically to manage work.
Email is great, and it's enough for IETF workgroups, but it's just a communication channel, it's far from an efficient tool to organize (track, show, share, plan) work.