Though I agree with a sibling comment that we might not find another system with the same advantages as CRISPR/Cas9 (ie, only having to generate RNAs to engineer site specificity, rather than the more intensive task of generating a protein coding sequence like you do with TALENs).
[0] https://www.ncbi.nlm.nih.gov/pubmed/21179091 [1] https://www.broadinstitute.org/what-broad/areas-focus/projec... [2] http://www.sciencemag.org/news/2018/09/new-gene-editing-trea...
I find it odd that we have state run/non-profit universities fighting over this. Something about the funding model at the academic level is truly fundamentally broken.
I have the feeling that there is a lot of progress being made in gene therapy technology these days. Having a friend who's life would be enhanced by gene therapy, I'm highly interested!
Edit: I should say that most of the gene therapy clinical trials don’t involve genome editing yet. Though it seems to me that, at least for some diseases, viral vectors that deliver DNA to cells without integrating DNA into the host cell genome (where the dna instead persists inside the cells episomally, and is maybe lost from the cells after some number of divisions) will have advantages over integrating vectors/genome editing-based approaches. That way, you don’t have to worry about the off-target effects of genome editing, and you have a treatment that doesn’t result in permanent changes to the genome.
https://write.narwhal.space/ was an attempt at making an instance for writers, but it seems to have gone into disrepair.