Pythonnet – A package that integrates Python (2.7-3.6) with the .NET CLR (opens in new tab)

How does removing .NET change anything ? You still need a runtime (GC, reflection/type information for casting, etc.)

You could probably strip down .NET core runtime if size is your concern and have an AoT compiled binary that links to that if you're concerned about JIT. I think there was a MS project a while back that compiled .NET IL to static code trough LLVM (https://github.com/dotnet/llilc - it seems dead now unfortunately)

But C# without .NET doesn't really make sense.

You mean like Netduino?

http://www.netduino.com/

Otherwise there are a few options already

https://www.toradex.com/windows-iot-starter-kit

https://developer.microsoft.com/en-us/windows/iot/Explore/de...

The problem with using C and Assembly instead of more productive options, when the hardware allows for it, is that many don't search properly.

I have to do funky validations on textfields. If the validation fails, make the field blink, or show an icon. Never allow a field to have input that fails validation (if you paste an invalid value, don't change the value of the field). I can do this several different ways in HTML and JS, or Java and one of it's UI frameworks (or my pivot framework, Qt). This apparently is hard to do with WPF. I solved it but the solution left me with a bad taste in my mouth. I shudder to think about other 'simple things' that I will have to torture a solution for given my experience. I would entertain the idea that I am a bad coder if I didn't have some experience delivering. I've spoken with a veteran WPF developer to see if I was misunderstanding something but apparently my solution was fine.