Normally they're used for OTPs or Chrome's FIDO U2F auth scheme, but you can also put them in smartcard mode. If you do this, you can use it as an OpenPGP key, which is also compatible with SSH:
https://www.esev.com/blog/post/2015-01-pgp-ssh-key-on-yubike... https://www.yubico.com/2012/12/yubikey-neo-openpgp/
Just about the only place that won't work is on a phone. Technically it has an independent NFC interface which could probably be made to work with some extra development, but I haven't looked into it.
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