Disney museum in presidio, by the golden gate. Really worth it.
As a bonus: Statue of Yoda a short walk/drive away at Lucas Arts, also in the presidio. Peek into the offices for some star wars memorabilia.
Companies - if you're into that: uber / twitter/ square ... all next to each other on Market St. Further into SOMA, around 4th and king, you can find many other startups.
South Park: little park area off 3rd street... where Twitter was 'founded'.
Random: Mrs. Doubtfire (Robin Williams movie) house in pacific height.
Cafe Jaqueline - in north beach - a favorite restaurant of Steve Jobs. I think it was mentioned in the Isaacson book.
