I struggle to do everything with Powershell, but almost everything I do has a mouse input. I use a gaming mouse for system administration - a Razer Naga Epic with the 12 thumb buttons.
They're a 3x4 array; I bind them to:
Row One
1. F5
2. Up arrow
3. F2
Row Two
4. Left arrow
5. Down arrow
6. Right arrow
Row Three
7. Tab
8. Delete
9. Backspace
Row Four
10. Enter
11. Spacebar
12. ESC
I can do the work of 2-3 admins, and I'm faster than poorly-written scripts.