Fair.
> single-handedly forced modernization in regulation and policy
Personal DNA kits were not pioneered by 23andme. The NHS in the UK sends out personal kits to test for colon cancer. One rather smart child, Jack Andraka [1], devised a personal kit to test for pancreatic cancer. And regulation in FDA policy is constantly shifting and changing. A notable such shift is due to a club set up by Ron Woodroof in 1988 [2].
23andme may have helped push science further, but single-handedly? Hardly. Science and discovery is a collaborative effort. They couldn't have done it without shoulders to stand on.
> built a mineable database of human genome data that is helping researchers find cures
The Human Genome project is a mineable database of chemical base pairs the make up human DNA. This has been an enabling technology used by researchers for drug and disease discovery since 1987 [3].
> and amassed nearly 1M paying customers.
The article you link to claims the number is closer to 850,000. A claim of 1M implies a relative error of 17.6%.
> I'd love for you to say that just because they aren't profitable means that they are a failure.
I agree that non-profitability does not imply failure.
May I ask what your affiliation with 23andme is?
[1] http://en.wikipedia.org/wiki/Jack_Andraka#Research_and_exper...
[2] http://en.wikipedia.org/wiki/Ron_Woodroof
[3] http://en.wikipedia.org/wiki/Human_Genome_Project#History