In that case, it doesn't matter how much security you have in your data center. Employees need access to central systems to do their job, so client security is paramount.
For instance, for a bank or Bitcoin exchange, I think it would relevant how many client operating systems can access your crown jewels. I think if you're just using Mac or Windows with antivirus or whatever, there's already a pretty low upper bound on your client security and thus your overall system security.
What I'm wondering if anybody is deploying some kind of custom client OS similar in spirit to Qubes OS, or a build of Chromium OS or Android, which have application sandboxing beyond what stock Linux, Mac or Windows have.
Also, I would imagine that each teller has their own credentials, and the bank should have policies about the transaction rate / total for a single teller. It sounds like the attackers would have to compromise multiple employee accounts to steal that much money. So you also want to protect employees machines from each other as much as possible (not just "outside" attackers).
I'm guessing that a Bitcoin Exchange doesn't have that many employees, since the whole industry is new. You probably have people just accessing stuff with their personal MacBooks or whatever, and that's fine for now (there are bigger risks). But when you start to have 100, 1000, 10,000 employees capable of doing financial damage, then I think this type of thing will start to matter more.
EDIT: Actually I remember one large deposit I made required three people at a bank to approve it. The teller said, "Wait my boss has to approve this." Then the boss said, "Wait my boss has to approve this". So they are probably using the presence of three credentials and credentials at a sufficient employee level to authorize large transactions. So I take it the attackers would have to target employees with those credentials.
But that can cause problems for customers -- e.g. if the branch manager isn't around, you might not be able to do what you wanted. To some degree, they are using meat space protocols to mitigate risk that their software systems can't handle.