Yes, you can. I've successfully done so in a Backbone/React app.
The _.chain() method furthermore gives a nice functional style ways of building lists which is useful when building UI in React, like so:
var list = _.chain([1, 2, 3, 4, 5])
.filter(function (value) {
return value > 2;
})
.map(function (value) {
return value;
});
console.log(list);
// prints:
// [3, 4, 5]