It's still the number one selling point and greatly reduces development time in both small and large applications.

The only thing I've seen is that in bigger projects, if there are locations where huge amounts of binding might take place (such as drawing, tables, etc...) you don't use two-way-binding in that particular place.

And in any case many of the popular frameworks (Ember, backbone etc... ) also use two-way binding, they just don't support two-way binding on simple js objects. And for that many of the bigger frameworks (