As a "professional" C/C++ programmer (day job), I don't have strong feelings either way. It is frustrating not knowing what the type of a variable is. Am I being passed a pointer, or an integer, or a floating point value, or a whole struct, or what? This really matters! Digging up the definition isn't difficult, but isn't easy, either. I would lean against using typedefs liberally, but I don't feel strongly about it.

Personally I use typedefs as a shortcut. Rather than type boost::shared_ptr<const MyFavoriteClass> over and over, typedef it to ConstMyFavoriteClassPtr for convenience. Then be consistent with that paradigm through the whole project, so you only have to learn it once to know any given Ptr type.