Microsoft AV, Norton, McAfee, etc. We know this, how? Because we can look at Google's virustotal and see when a sample was first submitted and when it was "detected." With typical malware there is a fairly short window between A and B, with US G malware there is a HUGE window (months, sometimes years).
Either the US G just gets very lucky that their samples aren't ever looked at deeper or more likely they have national security agreements with most of the large US based anti-virus firms to hush hush.