I'll stop running Adblock the day not running it stops being like walking through a lion's den with raw antelope strapped to your danglies.
Ad networks have always had (a very small %, but still there) a problem with people using exploits in flash ads. Especially ad networks for more 'dodgy' sites, that auto enable ads with no checking, no real checking if the advertiser is a legit business etc... (not that the adnetwork that this post is talking about deals with dodgy sites, but just saying its a common-ish problem (when given the 100s of thousands of ad impressions every day by ad networks).
I think i heard that malware nowadays is spread through more ads on adult websites (via 3rd party ad networks, not the sites themselves) than any other method, but i'm not sure on the source for that.