After using the ergonomically suicidal Apple Magic Mouse and Apple wireless keyboard, I developed RSI after just a couple of months. I having my wrists and forearms massaged every night until the tightness went away (for the night), and I switched to a mechanical keyboard, a nice-sized gaming mouse, and started mousing with my left hand at work.
I haven't had any RSI symptoms for over 2 years, and still just alternate mousing hands (left-handed at work, right-handed at home), and use a mechanical keyboard without a 10-key (keeps your mouse closer to a neutral position for your body).
Here's what I use at work, if anyone is interested:
Mouse: http://www.amazon.com/Razer-Deathadder-Infrared-Gaming-Mouse...
Keyboard: http://www.amazon.com/Storm-QuickFire-Rapid-Tenkeyless-Mecha...