Do you believe that neuroplasticity remains constant throughout a person's lifetime? Unless you believe that, your statement is incoherent.
Lesions and scars are acute changes in the brain that happen after birth. That's different from starting out missing massive chunk of your brain.
OP: "Look at that person who was born with no arms due to a birth defect. They're able to live a fairly normal, happy life. Maybe arms aren't essential to human happiness."
You: "So you're saying if you got your hand mutilated in a garbage disposal, that wouldn't make you unhappy? A hand is much less than a whole arm."
(I'll leave what this makes you a demonstration of as an exercise for the reader.)