I asked something about this myself a long while back: http://news.ycombinator.com/item?id=181010
If you have your "showdead" flag on settings, you'll see some comments there that are kind of anti-SimpleCDN from people who had commented on nothing else before and/or just signed-up that day to comment. I'm not sure whether that's someone trying to discredit them or just a coincidence.
We considered using them (and played with their service a tad), but Cloudfront has been working well enough for our needs (since we also use S3 a lot).
Also their routing system routes me to Chicago even though I'm based in London.
http://www.brightyellowcow.com/blog/Video-Streaming-Be-your-...