I also feel that same drive where I get restless when I feel my talents are being wasted. I think a lot of people do. But when my talents are actually being used, I don't feel miserable or unhappy, but rather content. I think this may be because I don't think in terms of "Am I accomplishing everything I set out to do? Have I made enough of a mark on the world?", but rather in terms of "Am I doing the right things? Am I following the path that will maximize my contributions to the world, given the information I have available?" (Okay, admittedly I've fallen into thinking like the former on occasion, and I tend to become miserably neurotic when I do. But I've worked pretty hard to try and view things in the latter light.)

The former puts the locus of control on the outside world, where you feel responsible for the effects of your actions, even if those effects are outside your control. The latter puts the locus of control on yourself, about your choices. In theory (and in my experience), success follows as a consequence of doing the right things, not as a cause.

And then when I find that something is preventing me from doing the right thing, I ask what it is. Very often, it's myself, and I have some internal fear I need to face and get over. Sometimes, it's someone else, in which case it's time to cut that person or organization out of my life.