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Is there an explanation as to why this would be the case (if it is)? With a lot of vitamins the argument is over absorbability of different forms, e.g. there are various forms of dietary calcium, and various kinds of calcium supplements, and they may not be equivalent. But my understanding was that fructose in fruit is pretty much just fructose, readily absorbable just like the isolated version is. The only plausible difference I can come up is concentration; there's a limit on how much fructose you can get from fruits because the average person is not going to scarf down a half-dozen pears in a sitting. But if high concentrations are the issue, it would also apply to concentrated "natural" fructose, e.g. the pear-juice concentrate that some "naturally sweetened" products use.