It's inappropriate to do various things that hurt people around you; but it's perfectly fine to vote and support laws that directly affect quality of life of people in both directions (surprise - pretty much all laws/propositions do!).

It's exactly the same as boycotting a company because CEO belongs to a really opposite political party - USA doesn't have any really opposite parties; but the rest of the world has seen quite a lot of such partisanism, and it ends up just as ugly as any other bigotry.