Ok, so outside of the immediate fireball, the majority of immediate damage is going to be caused by overpressure, which will obey square distance law. So you're 20x weapon will only cause ~4.5x the overpressure at some distance.
So now its civil engineering of modern buildings vs whatever they had at Nagasaki/Hiroshima. I honestly cannot answer this, but I suspect that they could probably sustain twice the overpressure at least. So you're actual lethality (from building collapse) at set distance is only about ~2x despite the ~10x increase in weapon power.
Now, it's all kinda moot cause there's not going to be 'just one nuke'.
For your enjoyment and horror, http://www.nuclearsecrecy.com/nukemap/ you can watch how dead you'll be.