The 'second' Klan was originally a merchandizing effort surrounding the movie "Birth of a Nation." It quickly turned into an actual political organization which adopted the white nativist views which were in vogue at the time. It was largely anti-immigrant focusing on Catholics, but also targeting Jews and Eastern Europeans.
It's worth noting that in all of it's incarnations, the Klan was racist and anti-black. It wasn't until the 1960s that this became the center-point of their politics, but it was always there.