Yep. I haven't done much with AirBnB and its ilk but I do often try to go the B&B route rather than the-big-chain-hotel (or even the smaller not-so-chain-hotel) route. But, as you say, especially for business travel, a lot of the time I just want something predictable that meets a certain standard. I don't want to be concerned that if my plans change and I don't get in until 9 that there won't be anyone there to let me in, etc. I frankly just don't have the mental energy to deal with on-offs for the whole 1/3 of the year or so I travel.
If the only thing that is causing you grief is the check-in check-out process, it is worth noting that some owners do try to streamline this process as much as possible. I for one try to keep contact with the person down to a minimum. Because you guys are right, I don't want to talk to anyone after 12 hours of travel.