JSON is parsed in C with CPython, or in assembly with PyPy.
As a real world example, I've done realtime image processing of a gigabyte per second worth of data on a single machine with asynchronous python. It was IO bound, we had more CPU to spare. Hell, we even had some GPUs sitting there not doing anything because they weren't needed.
If you're doing real performance computing, then taking advantage of GPUs/DSP or other hardware is where it is at anyway. Python is quite good at a glue language for interfacing to these things.