Not me. I run it on Linux. Fedora Linux on my personal laptop, and Ubuntu on my $DAYJOB machine.
I never notice memory because I never run out of memory. Where configs is everyone using that memory is such an issue?
It's not so much about running out of memory, as just the fact that Eclipse consumes a lot of memory, which means it doesn't play nice with other apps. I have 4GB of RAM in my $DAYJOB machine, running 64bit Ubuntu, and after I load Eclipse 4.2 with a few projects open, it's not uncommon to find the resident image size sitting at over 1GB. So, that wouldn't be a problem in isolation, but now add in an instance of JBoss running, PostgreSQL, a few browser windows with a bunch of tabs open, a PgAdminIII window, a couple of Gnome Terminal windows, etc. and pretty soon the hard-drive is just thrashing like crazy, essentially freezing the entire system, for minutes at a time. To be fair, everything is contributing to that, but Eclipse is one of the main culprits.