Yes, there is a factor of around 4x slowdown between asm.js optimizations and without them, on the next slide. But even 4x slower than asm.js is quite fast, it's enough to run the Epic Citadel demo for example (try it on a version of firefox without those optimizations, like stable release - as others reported in comments, it runs ok). A lot of the work in Epic Citadel is on the GPU anyhow, say it's about half, so the difference is then only something like 2x.
2x is not that much, we have similar differences on the web anyhow because of CPU differences, JIT differences, etc. That's within the expected range of variance.
Also, asm.js code is faster even without special optimizations compared to handwritten JS (see for example http://blog.j15r.com/blog/2011/12/15/Box2D_as_a_Measure_of_R... and http://blog.j15r.com/blog/2013/04/25/Box2d_Revisited ). So even without those optimizations it is worthwhile.