It's the fastest tool, but it does require knowing how to draw straight lines.
It also leaves management under no illusion that the thing is "almost done".
I work at a company in the top 15 of the Fortune 500.
When you export, you can export to a working clickable mockup with notes and things on it. I've felt pretty darn productive with Axure and that's why I recommend it.
You can make working dropdown menus too.
It produces a lot of absolute positioned css code, so it's not integrated with any web framework but does render pixel perfect.
I'm not sure how it would handle a responsive site, probably not, but you could quickly mockup the mobile version though.
You might also look at Corel Draw too.
If you want free, again Pencil, Inkscape or try the Google Draw templates - http://mortenjust.com/2010/04/19/a-wireframe-kit-for-google-...
another recommend for draw.io and also look the maqueta software - http://maqetta.org/news/2011/ibm-contributes-maqetta-html5-v...
I have also seen Jetstrap (https://www.jetstrap.com/) and it looks very cool but haven't tried it myself.
[EDIT] Fixed Typo.
Right now I just bought a $4 pad of news print from BLICK. It's cheap and I can use it on the airplane which is where I'll be tomorrow. HTH!
You transform designs into beautiful, interactive web & mobile mockups and you can receive feedback and collaboration in real time inside the mockups