I had another hard drive fail on me last week. At this point I would give part of my soul for SSD-style failure properties with sizes and prices comparable to conventional hard drives. (I mean, assuming partial souls regenerate, Xanth-style.)
I'm sure it will happen in a few years. I wonder if there's some starup opportunity here: are there any ways to take advantage of fast, reliable, cheap, flash-like storage becoming ubiquitous?
Probably you could add more fine-grained extension hooks to programs without them becoming bloated, by having plugins loaded lazily at run-time from a solid state drive. I'm convinced that the next big thing will be software that quietly integrates with other software, so you don't even have to click on an icon to use it.