This American Life http://feeds.thisamericanlife.org/talpodcast
BackStory with the American History Guys http://feeds.feedburner.com/BackStoryRadio
Freakonomics Radio http://feeds.feedburner.com/freakonomicsradio
Fresh Air Podcast http://www.npr.org/rss/podcast.php?id=13
Here's The Thing http://feeds.wnyc.org/wnycheresthething/
The Moth Podcast http://feeds.feedburner.com/themothpodcast
On the Media http://feeds.wnyc.org/onthemedia
Person Place Thing with Randy Cohen (man, I miss "The Ethicist") http://personplacething.org/?feed=rss2
Planet Money Podcast http://www.npr.org/rss/podcast.php?id=510289
WNYC's Radiolab http://feeds.wnyc.org/radiolab
To the Best of Our Knowledge http://feeds.feedburner.com/ttbook
With Good Reason Radio http://feeds.feedburner.com/WithGoodReasonRadio
I was tempted to put them in preferential order, but to be honest the go-to podcast depends on how much time I have (length of commute, how tired before bed, that kind of thing).
TWIT is always pretty fun as well (http://twit.tv/show/this-week-in-tech/)
Smithsonian puts out an interesting presentation every so often too (http://www.si.edu/podcasts/)
Granted these are all great podcasts, but they've been around and entertaining way before 2012.
Web devs: http://flapcast.com/playlist/16
Entrepreneurs: http://flapcast.com/playlist/18
There are a variety of podcasts in there, just click on each episode link to see the rest of the podcast's archive.
Also, Personal favorites this year:
http://www.creativemornings.com/ http://unity3d.com/unite/archive/2012
Old School Toughness from Hardcore history. feed://feeds.feedburner.com/dancarlin/history?format=xml
[1] http://www.youtube.com/user/mohammedabshaun/videos?view=0
Interviews: Conversations with Richard Fidler http://abc.net.au/queensland/conversations/conversationspodc...
- Skeptics Guide to the Universe ( http://www.theskepticsguide.org/ ) - Cognitive Dissonance ( http://dissonancepod.com/ )
Not technical at all, it focuses mostly on music, culture and art with some politics.
Ruby Tapas: http://devblog.avdi.org/rubytapas/
Great group of folks talking about design-focused startups and a lot of cool front-end tech.
Du Nord Football Show.
Responsible sports.
I prefer to read about tech.
Lapham's Quarterly