Larger tiles are used by apps that need to convey more information - your email app that just shows an unread count probably doesn't need more than the standard 1x1 tile, your newsreader might want a 2x1 to have room for headlines.
I'm not a huge fan of Metro, though I have been actively devving for Win8 for a few weeks. I don't think this is really a problem - all of this stuff is pretty obvious to users.