Just as it was before, but less-so now, it all comes down to who you want viewing your site. There is no single rule about what your site needs to adhere to, nor a single set of best practices that are appropriate for everything.
If you are concerned about your users, a lot of people these days are basically sacrificing accessibility for a better user experience for the non-visually impaired users with a recent browser. That is a bigger problem than web-safe colors by far. Web accessibility may eventually become subject to the ADA: http://www.ada.gov/
