It's going to be harder and harder to determine the legitimacy of a post or reply.
There will be no good way to determine if your speaking to a human because it will become completly indistinguishable.
The good news for HN is it's slightly easier to navigate and use judgement with post history.
What can you do with a lot of high karma accounts? Alot. Planting seeds in this community can go a very long way.