Assuming you don't believe humans have any metaphysical component, then the only remaining question is whether there's some essential component to being human that depends on impossible-to-precisely-simulate portions of reality. Nothing we currently know of biology suggests that that would be true, as much as it continues being pursued by people who
need there to be something mysterious about consciousness or brains.
In any case, a closely-but-not-perfectly-accurate simulation of a real human brain is still going to be human, unless you believe that someone becomes less human when they're experiencing some kind of cognitive decline, or a stroke, or other biological malfunctions. The point is, there is nothing essential to the having of a physical brain that creates the concept of consciousness or sense-of-self.
