The DEBUG utility was originally named DEBUG.COM in early versions
of MS-DOS, but it was renamed to DEBUG.EXE starting with MS-DOS 3.2
Then even after std lowlevel it was worth using Spinrite to check if interleave value was proper. And if it wasn't it was worth letting it first before anything else. Same when changing a faster CPU as it could speed up IO so much that no interleave would not needed any more and get faster IO.
Spinrite was such a great tool and time saver fixing or making preventive periodic maintenance to customers disks, even though it chugged hours even 30M disks. And just because not to take absolutely any risk it was necessary to make full backup first, which that took quote long also. LapLink was a great tool for that, before LAN became more common.
And yes, some of us are either old enough that we remember DEBUG.COM, or we got started way too young.
The debug.com binary only showed one measly ASM instruction at a time as I recall. Shudder.
https://www.nea.gov.sg/corporate-functions/resources/researc...
https://blog.debug.com/2019/11/singapore-collaboration-achie...
https://www.youtube.com/watch?v=M4k5xfrkR4Y https://www.youtube.com/watch?v=cH57Oo-FYQ8 https://www.youtube.com/watch?v=zAcxBNcAV00 https://www.youtube.com/watch?v=GGiCO_4EqoU
It's been so long since I've heard about Debug that I was afraid it was cancelled.
Lisa: But isn't that a bit short-sighted? What happens when we're overrun by lizards?
Principal Skinner: No problem. We simply unleash wave after wave of Chinese needle snakes. They'll wipe out the lizards.
Lisa: But aren't the snakes even worse?
Principal Skinner: Yes, but we're prepared for that. We've lined up a fabulous type of gorilla that thrives on snake meat.
Lisa: Then we're stuck with gorillas!
Principal Skinner: No, that's the beautiful part. When wintertime rolls around, the gorillas simply freeze to death.
This isn't a project to eliminate all mosquitos. There are over 3600 species of mosquito - this project is only targeting one: Aedes aegypti, which spreads many diseases, and is in fact an invasive species. Anywhere you see an Aedes aegypti outside of North Africa, it was humans who brought it there in the first place. This project is just trying to undo that.
My twisted brain spun out a version of this paragraph from some kind of parallel universe Hacker News (presumably where humans aren't the dominant species on the planet) that said:
> Homo sapiens, which spreads many diseases, and is in fact an invasive species. Anywhere you see a Homo sapiens outside of North Africa, it was humans who brought it there in the first place.
I think it's fun that my brain decided to come up spin the accepted African origin of humans and their proliferation around the world into this fun paragraph. No value judgement about humanity is implied.
Crazy that despite their progress behind the scenes, they appear to have not touched this website since.
I probably spent a little too much time tweaking the CSS to get the mosquitoes to not overlap the text on various viewport sizes :)
Release a few thousand females carrying a gene drive that produces all infertile males, and all fertile females (who all also have the same gene due to it being a gene drive). Every generation, there are more and more infertile males, and more and more fertile females carrying this extinction gene. After several generations (a.k.a. a few years), the population collapses completely.
I vote yes.
So from this armchair, I'm glad to see that at least for aedes aegypti (which seems like the clearest case for deploying a gene drive), there's an alternative like debug.
But any claim of completely wiping out a thriving species with a single action is doubtful. I'm all for trying this one, but I'm not bullish on its long-term success.
I wonder why we don't just try it on some remote island that has had mosquitoes introduced to it, but is otherwise considered isolated from the rest of the ecosystem (at least as far as mosquitoes are concerned).
This is addressed in their FAQ as well: "The general consensus among scientists is that the ecological impact of removing Aedes aegypti mosquitoes from urban environment would be small. They are not a significant food source for other animals and are invasive to many areas. The main ecological impact would be to restore the ecosystem to how it was before the mosquitoes invaded. Debug team is committed to working with communities and regulators to ensure the safety and acceptability of our field trials and releases."
In Indonesia for one they are. Every night, countless geckos come out, both indoors and outdoors, and start hunting for mosquitoes. Even lullabies sing about it [1].
The above song is so popular that it got an AI parody [2].
I'm curious what food chain reaction this will start if successful.
So...which areas is humanity native to?
Eliminating mosquitoes sounds great to me on the surface, but I wonder if it will have any adverse effects on any plants that rely on them for pollination, or if it's expected that there are plenty of other insects ready to fill any void they leave.
I think for the releasing-sterile-mosquitoes angle, it's actually more interesting to me to use some kind of molecular clock, I think I read about a genetic modification that resulted in a generation or two of fertile males, but then the Nth generation is sterile as a result of the molecular clock unwinding.
Linus's LinkedIn indicates debug moved from verily to google in Dec 2024 (I missed this at the time). Debug was always a passion project (unlikely to make a huge amount of money compared to ads, AI, and cloud) and Verily's transition to something that lost less money probably required them to move Debug back to Google.
Mosquitoes are a vector that spreads disease-causing germs to a population. The proposed solution is to use different mosquitoes as different vector that spreads a different disease-causing germ to a different population.
They won't harm then it sounds like, but they'll not fertilize the eggs.
However, it turns out the eggs are fertilized. Note that the FAQ says the males are effectively sterile and links here: https://en.wikipedia.org/wiki/Cytoplasmic_incompatibility
That wikipedia article says that there are embryos, but the embryos die.
However, the real question to ask, I guess, is whether the embryo is infected. As I read that article, it sounds like it isn't. Instead, the male parent is infected and this creates sperm which can fertilize the egg but in a way that creates an embryo that can't survive. In other words, the male parent has an infectious disease which causes the embryo to have a fatal genetic disease.
So this also brings up another question: what exactly is a vector? In this scenario, the embryo has a disease it would not otherwise have gotten, if it weren't for this germ. However, the embryo doesn't have the germ itself. Is being a vector defined by whether some disease is caused, or is it defined by whether the germ is spread? I don't know.
Hopefully all of these concerns have satisfactory answers, but the reference to it being a 1950s idea isn’t inspiring. Nuclear powered cars, widespread asbestos use, leaded gasoline, Freon… environmental impact wasn’t as big of a concern back then to put it mildly.
COVID proved that we can produce safe and effective vaccines extremely quickly if we actually try: so why not focus on that?
https://en.wikipedia.org/wiki/Neglected_tropical_diseases#Ec...
(intervention in a complex system, and without proper testing at that... even if the covid vaccines were safe, that was by luck)
We should go out of our way to avoid spraying insecticides in our lawns and other spaces. The lifecycle of the mosquito is much more rapid than that of fish, spiders, dragonflies, bats, etc. If you regularly nuke an area with insecticides, the mosquito population will have a lot less pressure to deal with.
I know this isn't attainable for most of the world but sharing in case someone else is similarly frustrated. I ended up spending $500 on a trap w/ co2 tank and it has been a life changer. I don't even see mosquitos anymore. Refilling the co2 is quite annoying and expensive ($20 every other week) and you have to clean out the 100s of bugs from the trap net but I can literally sit in my backyard all day again.
I wonder if a cheaper trap could be designed to give everyone little bubbles of safety.
Unless there's been some new announcement that I don't obviously see here?
Google wants to release up to 32M good mosquitoes California and Florida
https://ktla.com/news/google-wants-to-release-up-to-32-milli... (https://news.ycombinator.com/item?id=48351077)
https://www.theguardian.com/technology/2026/jun/01/google-pe...
(perhaps one of these should be the submitted link)
Google Mosquitoes - Debugging Florida
(probably the other way around, but what's the fun in that)
The Krogans got punitively infected with the genophage to drastically reduce successful births after their rebellion.
Don’t be so quick to rush to a verdict. We are still living with invasives we introduced with the same good intentions.
Some previous discussion:
We’re trying to stop bad mosquitoes by raising and releasing good ones (2016)
https://news.ycombinator.com/item?id=12657034
Google Has a Plan to Eliminate Mosquitoes (2018)
It makes me wonder if this kind of technology is deployed, where should the stop line be? And I don't think it's a trivial question.
Dr. Ian Malcolm in Jurassic Park
I might be an idiot.