Fentanyl remains a primary driver of overdose deaths, with synthetic opioids, primarily fentanyl, accounting for 60% of all overdose deaths in the United States last year, totaling about 48,000 people. While opioid overdose deaths remain high, there has been a decrease in fentanyl-involved deaths from 2023 to 2024. More National Fentanyl Overdose Data The CDC reports a 35.6% decrease in synthetic opioid overdose deaths from 2023 to 2024.