I use 2 and they work very well. No options for auto playing videos though.

1Blocker and AdGuard.

For 1Blocker I have everything enabled except adult content and scripts. AdGuard has everything turned off except for General.

These are just the free versions too.

I've been using this setup for a few years and it works close to 100% of the time.

If you're okay with merely effective, try using a DNS server based list from nextdns.io. This is not sophisticated like uBlock Origin, but it is effective. I use it on my phone and an old iPad in my kitchen that would otherwise be obliterated by the ads on cooking sites.