That our society’s economic strategy is effectively “how close can we skirt the line to serfdom and slavery” has no bearing on the devil’s advocate proposal of wholly-unregulated intoxicants that I’m replying to. The state will tend to deregulate so long as the intoxicant leaves workers inefficiently functional when they’re at work, but to strictly regulate when it impacts the job market; yet, neither of these tendencies have any bearing on whether we should regulate or not, they’re just inherent biases to be aware of when discussing our society.

As well, take care not to assume that to regulate is to make illegal, make medical-only, impose punitive taxes, etc. Sometimes the outcome of regulation is refusing to get involved — but even then, you do generally (at least, if prosocial societal goals are given sufficient precedence) see societies tend to impose some kind of either age limits or mandatory mentor or religious process onto intoxicants with regard to however they define ‘minors’, so that teenagers have to work for it, can be statistically discouraged en masse without tripping their biological contrarian responses, can be chaperoned by wiser adults, etc.