# From one's $HOME dir:
rm -fr ./.config/google-chrome/OptGuideOnDeviceModel
mkdir -p ./.config/google-chrome/OptGuideOnDeviceModel
touch ./.config/google-chrome/OptGuideOnDeviceModel/weights.bin
chmod 0400 ./.config/google-chrome/OptGuideOnDeviceModel/weights.bin
chmod 0500 ./.config/google-chrome/OptGuideOnDeviceModel
Adapt as appropriate for your OS. For "Chrome Unstable" installs, the dir name is google-chrome-unstable.This has, so far, kept Chrome from (re)installing that file on my system.
Hypothetically the parts involving weights.bin aren't needed so long as the containing directory is not writable.