Real talk: 6 layer oshpark is cheap enough for a hobbyist and there are a bunch of 500MHz / DDR2 parts that can be laid out. Like 0.8mm pitch BGAs can fit and breakout.
So yeah. Hobbyists can go here. But here be dragons!!
Nonetheless, I continue to assert that typical hobbyists are making mistakes at 100kHz region rather than the 100MHz region.