Yes, exactly. Whether it APOE mutation, traumatic injury, metabolic dysfunction, Herpes infection, or some other inflammation that upregulates kinases, you end up with hyperphosphorylated tau which in turn forms the neurofibrillary tangles that destroy nutrient transport in neurons and eventually kills them.

"Neuron death by protein aggregates" is the best way to define Alzheimer's. Anything more specific refers to only one of those aforementioned causes; anything less is just "brain don't work no more."

These clickbait headlines are so frustrating, especially since the article itself explains the tau mechanism and all the progress that has been made in understanding the disease.