The applications where the difference does not matter are those whose accuracy requirements are much less than provided by the numeric format that is used.
When using double-precision FP64 numbers, the rounding errors are frequently small enough to satisfy the requirements of an application, regardless if those requirements are specified as a relative error or as an absolute error.
In such cases, floating-point numbers must be used, because they are supported by the existing hardware.
But when an application has more strict requirements for the maximum absolute error, there are cases when it is preferable to use smaller fixed-point formats instead of bigger floating-point formats, especially when FP64 is not sufficient, so quadruple-precision floating-point numbers would be needed, for which there is only seldom hardware support, so they must be implemented in software anyway, preferably as double-double-precision numbers.