The requirement is simply that the app does AAAA queries, and that it attempts to connect to them if they exist. It doesn't matter whether the server does v6 natively or if the ISP is covering for a v4-only server via backwards compatibility. (Native v6 will probably perform better, but any site that wants to give up that advantage is free to do so.)
What’s nicer is 464XLAT, or more generally NAT64 prefix announcements. Then your local OS can just synthesize NAT64 addresses from v4 literals, either at the socket library or kernel networking (via “bump in the stack” translation) layer.
