Then there's nuclear defenses - if a country would have an effective anti-ICBM system (like Star Wars or whatever), it would make a nuclear counterstrike ineffective and end Mutually Assured Destruction. On paper anyway, in practice there are no perfect anti-ICBM systems, and they're effectively cluster bombs so in theory after the initial launch they can break up into half a dozen "dumb" nukes. Good luck hitting those.