The same with some multimedia CD's from its day. Scummvm it's partially implementing Macromedia Director support but the mentioned game had a custom engine. The Scummvm devs would RE in few weeks (it's a simple 2D game bundle, nothing difficult, with virtually no animations, almost everything it's still images) but no one began yet.

AFAICT, Wine can run WIN16 programs. I don't know if it can run DOS programs. There's a WineHQ wiki page that says it can load DOS programs, but various internet fora seem to believe that Wine's DOS support is pretty broken. I've never tried it, and have no DOS programs handy, so I can't verify those claims.