I dual boot LTSC and Fedora. I find myself using fedora more and more, but I need Windows for a couple of apps that don't play nicely with Wine/Proton (Ableton Live 12 mainly).
I recommend using one of those windows in a vm containers that just stream the application over rdp/x11/vnc. It looks like a native app depending on your desktop.
hmm direct pipewire sink seems to be negligeable, but you could always pcie passthrough an audio card if you need latency to be measured in microseconds.