I've only seen 34 qubit simulators (eg AWS SV1). My understanding is that 34 qubit uses 512GB of RAM, and each additional qubit doubles the RAM requirement. So, 50 qubit simulated would require 16.8M GB of RAM.
100 logical qubits seems to be the minimal threshold for interesting/useful quantum computing, albeit with very limited use cases. Classical still beats most. Quantinuum will hit that number in 2027. And, IonQ (often cited as being a hype-machine) expected to have 800 logical qubits in 2027.
The industry is moving out of the NISQ Era (noisy-intermediate-scale-quantum) and into the Fault-Tolerant QC (FTQC) era. NISQ is experimental. FTQC is commercial (ie reliable, repeatable).