You choose to do business in a jurisdiction, you bind yourself to their laws. That means all laws, not just ones you like, or think that are relevant to your business. Laws are not a buffet.
Don't do business in jurisdictions where you feel like you cannot comply with domestic law. No one is requiring you to do business in the US. People choose to do business in the US so they can profit from US customers, and that's totally fine, but doesn't come with some magical immunity to US law.
1. This isn't about business but charges. There's no way in hell US can e.g. prosecute non us citizens from trading with Cuba e.g. the embargo applies to US individuals and companies. The rest of the world, e.g. European countries, have normal relations with Cuba and nobody gives two damns about the embargo.
2. The same thing happens in reverse and applies to US companies doing business overseas.
Anyone who sells to my enemies is my enemy. You yourself can be subject to embargoes.
Francesca Albanese cannot do banking with banks from her own country because the US said so. Read: third parties that have relations with the US are barred from doing business with you or else risk being blacklisted too.
https://english.elpais.com/international/2025-12-28/the-comp...
Sure it can. It can do whatever it wants in its domestic courts. Turkmenistan can prosecute you and me right now for failure to pay insufficient deference to dear leader. Whether this impacts us in any way is the actual question. We presumably do not want to do business in Turkmenistan. But the OP wants to do business in the US. Ergo, the OP is subject to US law, irrespective of what he thinks US law should look like or what its limits ought to be.
OP doesn't have to do business in the US at all and be completely and utterly untouched by US law - he won't be extradited anywhere unless the offence in question is also an offence in his own country, which as you point out, the Cuban embargo (etc) isn't. This is how you and I stay safe from the many Turkmenistani indictments hanging over us.
This is not a case of someone bravely standing up for justice and freedom, this is a case of someone wanting to profit from US customers but somehow have total immunity from US law. And I'd respectfully point out that if the countries were reversed, and we were talking about e.g. Russia, the European countries would be apoplectic about anyone doing business there. Imagine a Brazilian company selling drone motors to Russia. Can its executives expect to travel freely through the EU without fear of arrest? Do business in the EU?